Swiss Learning Health System: A national initiative to establish learning cycles for continuous health system improvement.
The health system in Switzerland is taken into account as the most effective on the earth. Nevertheless, to successfully and effectively meet present and future challenges, an infrastructure and tradition are wanted the place the very best proof is systematically made out there and used, and the system evolves on the premise of a continuing trade between analysis, coverage, and apply.
The Swiss Learning Health System institutionalizes this concept as a multistakeholder national initiative to guarantee continuous enchancment by means of ongoing analysis and implementation. This article presents the aims and mechanisms of the Swiss Learning Health System within the context of worldwide initiatives to strengthen health programs and enhance inhabitants health by means of learning cycles.
A nation-wide initiative for mind imaging and medical phenotype knowledge federation in Swiss college reminiscence centres.
The purpose of our nation-wide initiative is to present clinicians intuitive and strong instruments for correct analysis, remedy monitoring and prognosis of cognitive decline that’s primarily based on large-scale multidomain knowledge.We describe a federation framework that permits for statistical evaluation of aggregated mind imaging and medical phenotyping knowledge throughout reminiscence clinics in Switzerland.
) IL-8 (-5 to +5) |
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| 5-01377 | CHI Scientific | 4 x 5mg | Ask for price |
 Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-100ug |
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| QP8982-ye-100ug | EnQuireBio | 100ug | EUR 670 |
 Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-10ug |
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| QP8982-ye-10ug | EnQuireBio | 10ug | EUR 308 |
 Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-1mg |
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| QP8982-ye-1mg | EnQuireBio | 1mg | EUR 2747 |
 Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-200ug |
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| QP8982-ye-200ug | EnQuireBio | 200ug | EUR 1069 |
 Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-500ug |
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| QP8982-ye-500ug | EnQuireBio | 500ug | EUR 1804 |
 Recombinant Human ANXA5/ Annexin 5/ Annexin A5 Protein, His, Yeast-50ug |
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| QP8982-ye-50ug | EnQuireBio | 50ug | EUR 417 |
) Annexin 1 (ANXA - 1; Ac 2 - 12) |
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| 5-00700 | CHI Scientific | 4 x 5mg | Ask for price |
 2',3',5'-triacetyl-5-Azacytidine |
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| C4119-5 | ApexBio | 5 mg | EUR 118 |
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Description: 2',3',5'-triacetyl-5-Azacytidine (TAC) is the lead prodrug form of 5-azacytidine which may be rapidly absorbed after oral administration [1]. 5-Azacytidine is an inhibitor of DNA methyltransferase [2]. |
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2',3',5'-triacetyl-5-Azacytidine |
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| B2822-5 | Biovision | EUR 153 | |
 Histatin 5 |
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| 5-01307 | CHI Scientific | 4 x 1mg | Ask for price |
 5-Iodotubercidin |
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| A3125-5 | ApexBio | 5 mg | EUR 168 |
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Description: 5-Iodotubercidin (Itu) is a purine derivative and hence an inhibitor of adenosine kinase with an IC50 value of 26 nM [1]. Adenosine kinase is important in regulating the intracellular and extracellular concentrations of adenosine and hence diverse physiological actions of adenosine [2]. |
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 5-ROX |
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| B8212-5 | ApexBio | 5 mg | EUR 195 |
 GNF-5 |
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| B1329-5 | Biovision | EUR 142 | |
 Necrostatin-5 |
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| 1865-5 | Biovision | EUR 126 | |
 Aftin-5 |
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| 2575-5 | Biovision | EUR 457 | |
 CHD-5 |
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| 2693-5 | Biovision | EUR 153 | |
) Thrombin Receptor Activator for Peptide 5 (TRAP-5) |
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| A1036-5 | ApexBio | 5 mg | EUR 102 |
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Description: Thrombin Receptor Activator for Peptide 5 (TRAP-5),(C30H50N8O7), a peptide with the sequence NH2-Ser-Phe-Leu-Leu-Arg-COOH, MW= 634.76. coagulation factor II (thrombin) receptor is a G protein-coupled receptor involved in the regulation of thrombotic response. |
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 [Cit5]-TRAP-5 |
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| 5-00062 | CHI Scientific | 4 x 5mg | Ask for price |
 A-VI-5 |
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| 5-00524 | CHI Scientific | 4 x 5mg | Ask for price |
) ACTH(5-10) |
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| 5-00605 | CHI Scientific | 4 x 5mg | Ask for price |
) Angiotensin (1-5) |
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| 5-00676 | CHI Scientific | 4 x 5mg | Ask for price |
) Bradykinin (1-5) |
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| 5-00852 | CHI Scientific | 4 x 5mg | Ask for price |
 TRAP-5 amide |
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| 5-02019 | CHI Scientific | 4 x 5mg | Ask for price |
 5-fluoro 203 |
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| C4114-5 | ApexBio | 5 mg | EUR 154 |
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Description: 5-fluoro 203 (5F-203) is an antitumor agent and cytotoxic compound that acts as a potent AhR agonist [1][2][3]. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in regulating xenobiotic-metabolizing enzymes such as cytochrome P450. |
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 W-5 hydrochloride |
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| B6277-5 | ApexBio | 5 mg | EUR 116 |
 5-Nonyloxytryptamine oxalate |
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| B6496-5 | ApexBio | 5 mg | EUR 154 |
 Teicoplanin A2-5 |
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| C4938-5 | ApexBio | 5 mg | EUR 1157 |
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Description: Teicoplanin A2-5, derived from Actinoplanes teichomyceticus, is a glycopeptide antibiotic which produces a broad spectrum of antibiotic activity against gram-positive bacteria. |
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 5'-deoxy Thymidine |
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| C4692-5 | ApexBio | 5 mg | EUR 180 |
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Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. |
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 2',5'-Dideoxyadenosine |
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| 2770-5 | Biovision | EUR 240 | |
 ELISA Kit) 5-Formylcytosine (5-fC) ELISA Kit |
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| MET-5102-5 | Cell Biolabs | 5 x 96 assays | EUR 2283 |
 ELISA Kit) 5-Carboxylcytosine (5-caC) ELISA Kit |
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| MET-5103-5 | Cell Biolabs | 5 x 96 assays | EUR 2283 |
) Dok- 5 (263 - 275) |
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| 5-01048 | CHI Scientific | 4 x 5mg | Ask for price |
, porcine) Secretin (5 - 27), porcine |
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| 5-01917 | CHI Scientific | 4 x 1mg | Ask for price |
) SH2 Domain Ligand (5) |
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| 5-01929 | CHI Scientific | 4 x 5mg | Ask for price |
 Boc-5-Ava-OH |
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| 5-04607 | CHI Scientific | 25g | Ask for price |
Boc-5-Ava-OH |
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| 5-04608 | CHI Scientific | 100g | Ask for price |
 Fmoc-5-Ava-OH |
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| 5-04609 | CHI Scientific | 5g | Ask for price |
Fmoc-5-Ava-OH |
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| 5-04610 | CHI Scientific | 25g | Ask for price |
 5-trans U-46619 |
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| C4261-5 | ApexBio | 5 mg | EUR 538 |
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Description: 5-trans U-46619 is a minor impurity (2-5%) which variably exists in most commercial preparations of U-46619 [1]. U-46619 is a selective thromboxane A2 agonist involved in inducing platelet aggregation and vascular smooth muscle contraction [2]. |
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 2',5'-dideoxy Adenosine |
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| C3993-5 | ApexBio | 5 mg | EUR 189 |
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Description: 2',5'-dideoxy Adenosine, a nucleoside analog, is one of the first identified cell-permeable, P-site inhibitors of adenylate cyclase [1]. Adenylyl cyclase is an enzyme with key regulatory roles in almost all cells. |
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 FAM azide, 5- isomer |
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| A8117-5 | ApexBio | 5 mg | EUR 166 |
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Description: FAM azide for Click chemistry labeling. FAM remains one of the most popular fluorescent lablels for various application. Most instruments capable of fluorescence detection, ranging from plate readers to fluorescence microscopes, are able to work in FAM channel. |
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 ROX azide, 5- isomer |
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| A8126-5 | ApexBio | 5 mg | EUR 583 |
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Description: ROX (rhodamine-X) azide, solid material, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. ROX is a red-emitting rhodamine dye possessing high brightness and fluorescence quantum yield.Pure 5-isomer. |
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 TAMRA azide, 5- isomer |
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| A8129-5 | ApexBio | 5 mg | EUR 583 |
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Description: TAMRA (TMR, tetramethylrhodamine) azide, solid compound, and 10 mM solution in DMSO, labeling reagent for Click Chemistry. Pure 5-isomer.TAMRA is often used as FRET acceptor for FAM fluorophore. |
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carboxamidoadenosine) 5'-(N-Cyclopropyl)carboxamidoadenosine |
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| C4645-5 | ApexBio | 5 mg | EUR 128 |
 Individual Reaction Mix 5 |
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| G065-5 | ABM | 200 reactions | EUR 167 |
 5-Nitroso-8-quinolinol |
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| B2825-5 | Biovision | EUR 109 | |
 AICA riboside, 5'-phosphate |
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| 9416-5 | Biovision | EUR 153 | |
 Necrosis Inhibitor, Necrox-5 |
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| 2229-5 | Biovision | EUR 615 | |
 Antibody) Annexin VII (Annexin VII) Antibody |
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| abx230439-100ug | Abbexa | 100 ug | EUR 509 |
 Antibody) Annexin VIII (Annexin VIII) Antibody |
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| abx230440-100ug | Abbexa | 100 ug | EUR 481 |
 5 mL) Magnetic Beads (DNA) 5 mL |
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| P920-5 | 101Bio | - | Ask for price |
) [Pyr5]-Substance P (5-11) |
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| 5-00288 | CHI Scientific | 4 x 5mg | Ask for price |
) [Trp3, Arg5]-Ghrelin (1-5) |
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| 5-00313 | CHI Scientific | 4 x 5mg | Ask for price |
 (bovine)) beta-Casomorphin (1-5) (bovine) |
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| 5-00475 | CHI Scientific | 4 x 5mg | Ask for price |
) Angiotensin I/II (5-8) |
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| 5-00684 | CHI Scientific | 4 x 5mg | Ask for price |
 (desulfated)) Cholecystokinin Octapeptide (1-5) (desulfated) |
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| 5-00970 | CHI Scientific | 4 x 5mg | Ask for price |
 HIV-gp41-Antigenic Peptide 5 |
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| 5-01331 | CHI Scientific | 4 x 1mg | Ask for price |
-OH) Fmoc-Trp(5-OH)-OH |
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| 5-06939 | CHI Scientific | 5g | Ask for price |
Fmoc-Trp(5-OH)-OH |
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| 5-06940 | CHI Scientific | 25g | Ask for price |
 5?-dihydro-11-keto Testosterone |
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| C4317-5 | ApexBio | 5 mg | EUR 586 |
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Description: 5?-dihydro-11-keto Testosterone (11KDHT) is a full androgen receptor agonist comparable to dihydrotestosterone (DHT) [1][2][3]. |
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 Helioxanthin derivative 5-4-2 |
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| B4700-5 | ApexBio | 5 mg | EUR 683 |
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Description: Helioxanthin derivative 5-4-2, an analogue of helioxanthin (ACH126447), is a small-molecule inhibitor of HBV, HSV-1and HSV-2 virus with EC50 values of 0.08 ?M, 0.29 ?M and 0.16 ?M, respectively [1]. |
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) Angiotensin 1/2 (1-5) |
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| A1047-5 | ApexBio | 5 mg | EUR 119 |
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Description: Angiotensin I/II (1-5) is a peptide (ASP-ARG-VAL-TYR-ILE) that contains the amino acids 1-5 and is converted from Angiotensin I/II.Angiotensin I is formed by the action ofreninonangiotensinogen, an ?-2-globulin with 12 amino acids. |
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) Angiotensin 1/2 (5-7) |
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| A1049-5 | ApexBio | 5 mg | EUR 119 |
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Description: Angiotensin 1/2 (5-7), (C17H27N5O4), a peptide with the sequence H2N-Ile-His-Pro-OH, MW=365.43. Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. |
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 3,3',5'-Triiodo-L-thyronine |
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| C5014-5 | ApexBio | 5 mg | EUR 134 |
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Description: 3,3',5'-triiodo-L-thyronine (reverse T3 or rT3) and 3,5,3'-triiodo-L-thyronine (T3) are the metabolism of thyroxine (T4) [1]. 3,3',5'-Triiodo-L-thyronine is thyroid hormone receptors TR? and TR? antagonist [1]. |
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 2'-O-Methylpseudouridine-5'-Triphosphate |
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| B7993-.5 | ApexBio | 5x100 µl (100 mM) | EUR 14023 |
 2'-Fluoro-thymidine-5'-Triphosphate |
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| B8035-.5 | ApexBio | 5x100 µl (100 mM) | EUR 2059 |
 pLenti-CLDN1 shRNA-5 Plasmid |
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| PVTBAV04867-5 | Lifescience Market | 2 ug | EUR 356 |
3,3',5'-Triiodo-L-thyronine |
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| B2017-5 | Biovision | EUR 229 | |
 2-Methyl-5-hydroxytryptamine hydrochloride |
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| 2768-5 | Biovision | EUR 185 | |
 Anti-Annexin A10 / Annexin 14 antibody |
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| STJ70117 | St John's Laboratory | 100 µg | EUR 359 |
 Alleleustrious pmTFP1-Annexin fusion vector Annexin |
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| ABP-FP-TAN | Allele Biotech | 5 ug | Ask for price |
 Alleleustrious pWasabi-Annexin fusion vector Annexin |
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| ABP-FP-WAN | Allele Biotech | 5 ug | Ask for price |
 amide (bovine)) beta-Casomorphin (1-5) amide (bovine) |
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| 5-00476 | CHI Scientific | 4 x 5mg | Ask for price |
) cAMP Dependent PK Inhibitor (5-24) |
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| 5-00922 | CHI Scientific | 4 x 1mg | Ask for price |
) Kinase Domain of Insulin Receptor (5) |
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| 5-01429 | CHI Scientific | 4 x 1mg | Ask for price |
-OH) Fmoc-D-Trp(5-Br)-OH |
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| 5-04217 | CHI Scientific | 1g | Ask for price |
Fmoc-D-Trp(5-Br)-OH |
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| 5-04218 | CHI Scientific | 5g | Ask for price |
-OH) Fmoc-D-Trp(5-Cl)-OH |
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| 5-04223 | CHI Scientific | 1g | Ask for price |
Fmoc-D-Trp(5-Cl)-OH |
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| 5-04224 | CHI Scientific | 5g | Ask for price |
-OH) Fmoc-D-Trp(5-F)-OH |
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| 5-04227 | CHI Scientific | 1g | Ask for price |
Fmoc-D-Trp(5-F)-OH |
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| 5-04228 | CHI Scientific | 5g | Ask for price |
-OH·DCHA) Ac-DL-Trp(5-Br)-OH·DCHA |
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| 5-04229 | CHI Scientific | 1g | Ask for price |
Ac-DL-Trp(5-Br)-OH·DCHA |
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| 5-04230 | CHI Scientific | 5g | Ask for price |
-OH·DCHA) Ac-DL-Trp(5-Cl)-OH·DCHA |
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| 5-04231 | CHI Scientific | 1g | Ask for price |
Ac-DL-Trp(5-Cl)-OH·DCHA |
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| 5-04232 | CHI Scientific | 5g | Ask for price |
 Fmoc-2-amino-5-Methoxybenzoic acid |
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| 5-04549 | CHI Scientific | 1g | Ask for price |
Fmoc-2-amino-5-Methoxybenzoic acid |
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| 5-04550 | CHI Scientific | 5g | Ask for price |
-OH) Fmoc-3-Ala(5-Thiazoyl)-OH |
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| 5-05361 | CHI Scientific | 1g | Ask for price |
Fmoc-3-Ala(5-Thiazoyl)-OH |
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| 5-05362 | CHI Scientific | 5g | Ask for price |
 7078D 5 PIPET 5ML STERILE STERILE |
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| 7078D-5 | CORNING | 25/pk | EUR 217 |
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Description: Disposable Pipets; Disposable Pipets, Serological, Misc |
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-Amiloride (hydrochloride)) 5-(N,N-dimethyl)-Amiloride (hydrochloride) |
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| C3505-5 | ApexBio | 5 mg | EUR 180 |
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Description: 5-(N, N-dimethyl)-Amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of NHE1, NHE2, and NHE3. The Na+/H+ exchanger (NHE) is a protein that has been involved in intracellular pH homeostasis of many mammalian cell types. |
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 Beta-Sheet Breaker Peptide iA?5 |
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| A1005-5 | ApexBio | 5 mg | EUR 102 |
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Description: Beta-Sheet Breaker Peptide iA?5 (C33H43N5O8), with the sequence H-Leu-Pro-Phe-Phe-Asp-OH, has been shown to inhibit amyloidogenesis in rat brain models. |
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 2'-Fluoro-2'-deoxyadenosine-5'-Triphosphate |
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| B7959-.5 | ApexBio | 5x100 µl (100 mM) | EUR 2059 |
 2'-Fluoro-2'-deoxycytidine-5'-Triphosphate |
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| B7961-.5 | ApexBio | 5x100 µl (100 mM) | EUR 2059 |
 2'-Fluoro-2'-deoxyguanosine-5'-Triphosphate |
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| B7962-.5 | ApexBio | 5x100 µl (100 mM) | EUR 2059 |
 2'-Fluoro-2'-deoxyuridine-5'-Triphosphate |
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| B7963-.5 | ApexBio | 5x100 µl (100 mM) | EUR 2059 |
 3-bromo-5-phenyl Salicylic Acid |
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| C4516-5 | ApexBio | 5 mg | EUR 370 |
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Description: Ki: 140 nM for AKR1C1; 1.97 ?M for AKR1C2; 21 ?M for AKR1C3 3-bromo-5-phenyl Salicylic acid is an AKR1C1 inhibitor. |
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The adaptation and deployment of available knowledge capturing and federation modules is paralleled by developments in ontology, high quality and regulatory management of mind imaging knowledge. Our initiative incentivizes knowledge sharing by means of the frequent useful resource in a manner that gives particular person researcher with entry to large-scale knowledge that surpasses the info acquisition capability of a single centre.
Clinicians profit from fine-grained epidemiological characterization of personal knowledge in contrast with the remainder further to intuitive instruments permitting for computer-based analysis of dementia. Finally, our idea goals at closing the loop between group-level outcomes primarily based on mixture knowledge and particular person analysis by offering illness fashions, that’s, classifiers for neurocognitive problems that can allow the computer-based analysis of particular person sufferers.
The obtained outcomes will inform suggestions on finest medical apply in all related fields specializing in standardization and interoperability of acquired knowledge, privateness safety framework and moral consideration within the context of evolutive pathology.